Publications

Detection of preQ0 deazaguanine modifications in bacteriophage CAjan DNA using Nanopore sequencing reveals same hypermodification at two distinct DNA motifs (2020) Witold Kot,  Nikoline S Olsen,  Tue K Nielsen,  Geoffrey Hutinet,  Valérie de Crécy-Lagard, Liang Cui,  Peter C Dedon,  Alexander B Carstens,  Sylvain Moineau,  Manal A Swairjo, Lars H Hansen, Nucleic Acids Research, gkaa735, https://doi.org/10.1093/nar/gkaa735.

Specificity in the Biosynthesis of the Universal tRNA Nucleoside N6-Threonylcarbamoyl Adenosine (t6A) – TsaD is the Gatekeeper (2020) William E Swinehart, Christopher W Deutsch, Kathryn L Sarachan, Amit Luthra, Jo Marie Bacusmo, Valérie de Crécy-Lagard, Manal A Swairjo, Paul F Agris, Dirk Iwata-Reuyl, RNA, doi: 10.1261/rna.075747.120.

Structure-based design of guanosine analogue inhibitors targeting GTP cyclohydrolase IB towards a new class of antibiotics (2020) George N Samaan, Naduni Paranagama, Ayesha Haque, David A Hecht, Manal A Swairjo, Byron W Purse, Bioorganic & medicinal chemistry letters, Volume 30, Issue 2, 126818

Discovery of novel bacterial queuine salvage enzymes and pathways in human pathogens (2019), Yifeng Yuan, Rémi Zallot, Tyler L Grove, Daniel J Payan, Isabelle Martin-Verstraete, Sara Šepić, Seetharamsingh Balamkundu, Ramesh Neelakandan, Vinod K Gadi, Chuan-Fa Liu, Manal A Swairjo, Peter C Dedon, Steven C Almo, John A Gerlt, Valérie de Crécy-Lagard, Proceedings of the National Academy of Sciences 116 (38), 19126-19135

Conformational communication mediates the reset step in t6A biosynthesis (2019), Amit Luthra, Naduni Paranagama, William Swinehart, Susan Bayooz, Phuc Phan, Vanessa Quach, Jamie M Schiffer, Boguslaw Stec, Dirk Iwata-Reuyl, Manal A Swairjo, Nucleic acids research Volume 47, Issue 12, 09 July 2019, Pages 6551–6567

Inhibitor potency varies widely among tumor-relevant human isocitrate dehydrogenase 1 mutants (2018), Diego Avellaneda Matteo, Grace A Wells, Lucas A Luna, Adam J Grunseth, Olga Zagnitko, David A Scott, An Hoang, Amit Luthra, Manal A Swairjo, Jamie M Schiffer, Christal D Sohl, Biochemical Journal 475 (20), 3221-3238

Structure and mechanism of a bacterial t6A biosynthesis system (2018), Amit Luthra, William Swinehart, Susan Bayooz, Phuc Phan, Boguslaw Stec, Dirk Iwata-Reuyl, Manal A Swairjo, Nucleic acids research 46 (3) 1395-1411

Mechanism and catalytic strategy of the prokaryotic-specific GTP cyclohydrolase-IB (2017), Naduni Paranagama, Shilah A Bonnett, Jonathan Alvarez, Amit Luthra, Boguslaw Stec, Andrew Gustafson, Dirk Iwata-Reuyl, Manal A Swairjo, Biochemical Journal 474 (6), 1017-1039

Protection of the queuosine biosynthesis enzyme QueF from irreversible oxidation by a conserved intramolecular disulfide (2017), Adeba Mohammad, Adriana Bon Ramos, Bobby Lee, Spencer Cohen, Maryam Kiani, Dirk Iwata-Reuyl, Boguslaw Stec, Manal Swairjo, Biomolecules 7 (1), 30

Crystal structure of the archaeosine synthase QueF‐like—Insights into amidino transfer and tRNA recognition by the tunnel fold (2017), Xianghan Mei, Jonathan Alvarez, Adriana Bon Ramos, Uttamkumar Samanta, Dirk Iwata‐Reuyl, Manal A Swairjo, Proteins: Structure, Function, and Bioinformatics 85 (1), 103-116

Structural basis of biological nitrile reduction (2012), Vimbai M Chikwana, Boguslaw Stec, Bobby WK Lee, Valérie de Crécy-Lagard, Dirk Iwata-Reuyl, Manal A Swairjo, Journal of Biological Chemistry 287 (36), 30560-30570

Fluorescent Fatty Acid Transfer from Bovine Serum Albumin to Phospholipid Vesicles: Collision or Diffusion Mediated Uptake (2012), Bassam M Elmadhoun, Manal A Swairjo, Frank J Burczynski, Journal of Pharmacy & Pharmaceutical Sciences 15 (3), 420-432

Diversity of archaeosine synthesis in crenarchaeota (2012), Gabriela Phillips, Manal A Swairjo, Kirk W Gaston, Marc Bailly, Patrick A Limbach, Dirk Iwata-Reuyl, Valérie de Crécy-Lagard, ACS chemical biology 7 (2), 300-305

YrdC exhibits properties expected of a subunit for a tRNA threonylcarbamoyl transferase (2011), Kimberly A Harris, Victoria Jones, Yann Bilbille, Manal A Swairjo, Paul F Agris, RNA 17 (9), 1678-1687

Discovery and characterization of an amidinotransferase involved in the modification of archaeal tRNA (2010), Gabriela Phillips, Vimbai M Chikwana, Adrienne Maxwell, Basma El-Yacoubi, Manal A Swairjo, Dirk Iwata-Reuyl, Valérie de Crécy-Lagard, Journal of Biological Chemistry 285 (17), 12706-12713

Zinc-independent folate biosynthesis: genetic, biochemical, and structural investigations reveal new metal dependence for GTP cyclohydrolase IB (2009), Banumathi Sankaran, Shilah A Bonnett, Kinjal Shah, Scott Gabriel, Robert Reddy, Paul Schimmel, Dmitry A Rodionov, Valérie de Crécy-Lagard, John D Helmann, Dirk Iwata-Reuyl, Manal A Swairjo, Journal of bacteriology 191 (22), 6936-6949

The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA (2009), Basma El Yacoubi, Benjamin Lyons, Yulien Cruz, Robert Reddy, Brian Nordin, Fabio Agnelli, James R Williamson, Paul Schimmel, Manal A Swairjo, Valerie de Crecy-Lagard, Nucleic acids research 37 (9), 2894-2909

Discovery of a new prokaryotic type I GTP cyclohydrolase family (2006), Basma El Yacoubi, Shilah Bonnett, Jessica N Anderson, Manal A Swairjo, Dirk Iwata-Reuyl, Valérie de Crécy-Lagard, Journal of Biological Chemistry 281 (49), 37586-37593

Two conformations of a crystalline human tRNA synthetase–tRNA complex: implications for protein synthesis (2006), Xiang‐Lei Yang, Francella J Otero, Karla L Ewalt, Jianming Liu, Manal A Swairjo, Caroline Köhrer, Uttam L RajBhandary, Robert J Skene, Duncan E McRee, Paul Schimmel, The EMBO journal 25 (12), 2919-2929

Crystallization and preliminary X-ray characterization of the nitrile reductase QueF: a queuosine-biosynthesis enzyme (2005), Manal A Swairjo, Robert R Reddy, Bobby Lee, Steven G Van Lanen, Shannon Brown, Valérie de Crécy-Lagard, Dirk Iwata-Reuyl, Paul Schimmel, Acta Crystallographica Section F: Structural Biology and Crystallization Communications 61 (10), 945-948

From cyclohydrolase to oxidoreductase: discovery of nitrile reductase activity in a common fold (2005), Steven G Van Lanen, John S Reader, Manal A Swairjo, Valérie de Crécy-Lagard, Bobby Lee, Dirk Iwata-Reuyl, Proceedings of the National Academy of Sciences 102 (12), 4264-4269

Breaking sieve for steric exclusion of a noncognate amino acid from active site of a tRNA synthetase (2005), Manal A Swairjo, Paul R Schimmel, Proceedings of the National Academy of Sciences 102 (4), 988-993

Positional recognition of a tRNA determinant dependent on a peptide insertion (2004), Martha A Lovato, Manal A Swairjo, Paul Schimmel, Molecular cell 13 (6), 843-851

Alanyl-tRNA synthetase crystal structure and design for acceptor-stem recognition (2004), Manal A Swairjo, Francella J Otero, Xiang-Lei Yang, Martha A Lovato, Robert J Skene, Duncan E McRee, Lluis Ribas de Pouplana, Paul Schimmel, Molecular cell 13 (6), 829-841

Diversity of Archaeosine Synthesis in Crenarchaeota (2003), Manal A Swairjo, Kirk W Gaston, Marc Bailly, Patrick A Limbach, Dirk Iwata-Reuyl, Valérie de Crécy-Lagard, Bioorg Chem 31, 24-43

Crystal structure of trbp111: a structure‐specific tRNA‐binding protein (2000), Manal A Swairjo, Arturo J Morales, Chien‐Chia Wang, Angel R Ortiz, Paul Schimmel, The EMBO journal 19 (23), 6287-6298

Structure‐specific tRNA‐binding protein from the extreme thermophile Aquifex aeolicus (1999), Arturo J Morales, Manal A Swairjo, Paul Schimmel, The EMBO Journal 18 (12), 3475-3483

Structural Role of the 30’s Loop in Determining the Ligand Specificity of the Human Immunodeficiency Virus Protease (1998), Manal A Swairjo, Eric M Towler, Christine Debouck, Sherin S Abdel-Meguid, Biochemistry 37 (31), 10928-10936

Mutational and Crystallographic Analyses of Interfacial Residues in Annexin V Suggest Direct Interactions with Phospholipid Membrane Components (1998), B Campos, YD Mo, TR Mealy, CW Li, MA Swairjo, C Balch, JF Head, G Retzinger, JR Dedman, BA Seaton, Biochemistry 37 (22), 8004-8010

Annexin V mutant structures and properties (1997), C Balch, MB Campos, JR Dedman, CW Li, TR Mealy, MA Swairjo, BA Seaton, Biophysical Journal 72 (2), MP306-MP306

Ca 2+-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V (1995), MA Swairjo, NO Concha, MA Kaetzel, JR Dedman, BA Seaton, Nature structural biology 2 (11), 968

Annexin V binding to the outer leaflet of small unilamellar vesicles leads to altered inner leaflet properties: 31P-and 1H-NMR studies (1994), Manal A Swairjo, Mary F Roberts, Maria-Begona Campos, John R Dedman, Barbara A Seaton, Biochemistry 33 (36), 10944-10950

Annexin structure and membrane interactions: a molecular perspective (1994), Manal A Swairjo, Barbara A Seaton, Annual review of biophysics and biomolecular structure 23 (1), 193-213

Effect of vesicle composition and curvature on the dissociation of phosphatidic acid in small unilamellar vesicles-a 31P-NMR study (1994), Manal A Swairjo, Barbara A Seaton, Mary F Roberts, Biochimica et Biophysica Acta (BBA)-Biomembranes 1191 (2), 354-361

Crystallographic and spectroscopic solution studies of the interaction of rat annexin-V with ligands (1994), MA Swairjo, No Concha, JF Head, MB Campos, JR Dedman, MF Roberts, BA Seaton, Biophysical Journal 66 (2), A66-A66

Rat-kidney annexin-V structure and properties (1993), No Concha, MA Swairjo, JF Head, Ma Kaetzel, Jr Dedman, BA Seaton, Biophysical Journal 64 (2), A167-A167

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